Pesquisa sobre:
SUPPRESSOR OF CYTOKINE SIGNALING 3 PROTEIN
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DeCS
Descritor
Inglês
:
Suppressor of Cytokine Signaling 3 Protein
Descritor
Espanhol
:
proteína 3 supresora de la señalización de citocinas
Descritor
Português
:
Proteína 3 Supressora da Sinalização de Citocinas
Sinônimos
Inglês
:
Protein, SOCS3
SOCS3 Protein
Suppressor of Cytokine Signaling Protein 3
Categoria:
D12.644.360.024.374.750
D12.776.157.057.249.750
D12.776.476.024.437.750
Definição
Inglês
:
A suppressor of cytokine signaling protein that consists of an N-terminal kinase-inhibitory region, a central SH2 DOMAIN, a characteristic C-terminal SOCS box (a 40-amino acid motif, which functions to recruit E3
UBIQUITIN-PROTEIN LIGASE COMPLEXES
). SOCS3 inhibits cytokine signaling by binding to
RECEPTOR PROTEIN-TYROSINE KINASES
as well as
CYTOKINE RECEPTOR GP130
;
ERYTHROPOIETIN
RECEPTORS;
INSULIN
RECEPTOR; and the
LEPTIN
RECEPTOR. Its functions include
suppression
of
ERYTHROPOIESIS
in the fetal liver.
Nota Histórica
Inglês
:
2017
Qualificadores Permitidos
Inglês
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
DF
deficiency
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Número do Registro:
56544
Identificador Único:
D000071223
Ocorrência na BVS
:
Similar:
DeCS